Tryptophan probes reveal residue-specific phospholipid interactions of apolipoprotein C-III

Phospholipid–cytochrome c interactions

9 REVIEW OF THE LITERATURE 11 Structure of cytochrome c . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .11 Phospholipid binding by cyt c . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .12 Cyt c in apoptosis . ....

Reaction of a Specific Tryptophan Residue in Streptococcal

The zymogen and enzyme forms of streptococcal proteinase were treated with the tryptophan-specific reagent Z-hydroxy-5-nitrobenzyl bromide (HNB-Br) in 0.46 M phosphate solutions at pH 3.1. The zymogen failed to react with HNB-Br, and none of its potential activity was destroyed. The enzyme incorporated up to 1.8 HNB groups per molecule and lost a maximum of 95% its potential activity. Four pept...

Allele-specific differences in apolipoprotein C-III mRNA expression in human liver.

BACKGROUND Sequence variations at the apolipoprotein (apo)C-III gene locus have been associated with increased plasma triglycerides. In particular, the S2 allele of an SstI polymorphism in the 3' untranslated region has been associated with hypertriglyceridemia in many populations. The aim of this study was to determine whether the variant S2 allele is related to increased mRNA expression in vi...

Lipids: Apolipoprotein A-1 Apolipoprotein A-II Apolipoprotein B Apolipoprotein C-II Apolipoprotein C-III Apolipoprotein E Cholesterol Direct HDL Cholesterol Direct LDL Cholesterol Lipoprotein (a) sLDL Triglycerides

Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III

While a significant component of atherosclerotic plaques has been characterized as amyloid, the specific proteins remain to be fully identified. Probable amyloidogenic proteins are apolipoproteins (Apos), which are vital for the formation and function of lipoproteins. ApoCIII is an abundant protein implicated in atherosclerosis, and we show it forms a ribbonlike looped amyloid, strikingly simil...